This workshop, sponsored by AIM and the NSF, will bring together experts in mathematical modeling, biomedical engineering, and clinical research to advance multiscale modeling approaches that bridge ocular, cardiovascular, and systemic dynamics. The non-invasive nature of ocular measurements, such as retinal blood flow and intraocular pressure, provides a unique opportunity for early diagnosis and monitoring of conditions such as diabetes, hypertension, heart failure, and neurological disorders. However, translating these insights into clinical practice requires a strong collaboration between clinicians and modelers to design interpretable and actionable approaches. A key focus of the workshop will be integrating mechanistic models with data-driven approaches, balancing interpretability with predictive power.